![]() Ī large number of drugs can be transported into the seminal fluid, where they can have direct effects on sperm function, physiology, metabolism or genetic composition. In clinical trials, sildenafil has been shown to increase the duration and rigidity of penile erection in response to visual sexual stimuli in a hospital setting and to greatly enhance the ability to achieve erections, leading to successful completion of intercourse in the home setting. When administered before sexual activity, it produces reliable efficacy, good tolerability and rapid absorption that yields prompt onset of action it has a plasma half-life that produces an appropriate duration of action while avoiding accumulation on repeated once-daily use. Sildenafil citrate (Viagra®, Pfizer) is the first oral agent to be introduced for the management of ED. Available treatments were highly cumbersome or invasive, and many patients and their partners found them unacceptable solutions to the problem. Until recently, no effective oral therapy existed. ![]() Erectile dysfunction (ED) is a widespread condition that can have a negative impact on quality of life, affecting both older and younger men.
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June 2023
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